Dr. Megan McNerney, MD, PhD, is an Associate Professor in the Departments of Pathology and Pediatrics, Section of Hematology/Oncology, at The University of Chicago. She serves as Faculty Associate Director of Admissions, for the Medical Scientist Training Program. Dr. McNerney received her B.A. at Northwestern University and M.D. and Ph.D. at The University of Chicago. Her lab is investigating the pathobiology of high-risk myeloid neoplasms, particularly those that have lost all or part of chromosome 7. The McNerney lab has employed an arsenal of innovative wet and dry-lab approaches to interrogate 7q tumor suppressor genes. This work has uncovered the CUX1 transcription factor as a critical regulator of hematopoiesis. Her lab demonstrated that pre-existing CUX1-deficiency, in the context of clonal hematopoiesis, disrupts the epigenetic regulation of DNA repair and sensitizes mice to therapy-related myeloid neoplasms (t-MN) after chemotherapy, supporting a paradigm shift in understanding the etiology of t-MN. Ongoing work includes determining the mechanistic role of CUX1 in development and gene expression, and how 7q tumor suppressor genes cooperate in leukemogenesis.
Dr. McNerney has published over forty manuscripts. She has been recognized by several awards, most recently the Leukemia and Lymphoma Society Scholar award, the Pediatric Cancer Research – V Scholar All Star Award, and the university-wide Faculty Award for Excellence in Graduate Teaching and Mentoring.
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